WATCH: De Santis slams Biden administration as ‘lockdowners’ while Florida is thriving

Florida has been conspicuously not adhering to the administration's dictates on economic closures and restrictions intended to curb the COVID contagion, and it has benefitted, with people from across the country flocking to the Sunshine State.

"It would be unconstitutional," De Santis told Bartiromo, "it would be a political attack against Florida."

"If you look, Maria, right now, you hear this debate over schools. Florida schools have been open the whole school year. Every parent in Florida has the right to send their child for in-person instruction. Every worker has a right to work and earn a living and put food on their table. And every business has a right to operate and consequently, our state is doing very well compared to these other states in terms of education and economy.

"But," he continued, " we also have 26 other states, including the District of Columbia, that have higher per capita COVID mortality than we do. We have 28 states that have higher per capita cases than we do for the bulk of the pandemic.

"And if you look right now, states that are always held up by people in Biden's administration, like New York, have way higher per capita patients hospitalized for COVID right now. So there's no basis in medical, there's no basis in economics, there's no basis in reality to do this, except to punish a state that is doing it better than what his experts have recommended.

"Biden is a lockdowner, his advisors are lockdowners, lockdowns don't work. We've demonstrated that. We're not turning back Maria, and they will not be able to get away with targeting Florida," De Santis said.

De Santis touted Florida's unemployment rate as "significantly less than the national average," the increase in home sales, and new construction. He noted that the number one place for home construction in the country is The Villages retirement community.

He said that new hotels and businesses are starting up in Florida, and that seniors are being prioritized for the vaccine, saying "we're going to be first out of the gate once we're able to put COVID behind our country."